Jennifer Goodwyn, a Cornell University graduate student, inadvertently returns home to sleepy Ithaca, N.Y. from an archaeological dig at the Cenacle—the purported site of the Last Supper—with an ancient bone box. The ossuary is found to contain several pieces of early first century stoneware, and a mysterious, tiny scroll. When the Aramaic glyphs on the slip of crumbling papyrus are translated, they identify the humble dinner setting as the one used by a rabblerousing Nazarene rabbi at his Seder meal, on the evening he’d been arrested by the Romans.
One ill-considered impulse—asking a local parish priest to say Mass with the ceremonial Seder cup—sweeps Jennifer away to churches, cathedrals, sports stadiums, and to a powerful Cardinal's basilica to celebrate Mass with the vessel and to exhibit it before ever-growing crowds of believers.
But soon, all hell breaks loose. While the State Department is aggressively seeking its return to Israel, a nationwide political movement starts rising up around the relic. And Jennifer soon discovers that the storied artifact is causing sickness and even death among those who remain too long in its presence. In an effort to stem the political mayhem and insure the safety of the faithful, Jennifer hits the road, trying to stay one step ahead of the feds until she can find a way to quell the growing public chaos unleashed by the revelations of The Cenacle Scroll.